Regulation of bacterial gene expression. The transcriptional regulators we study program antibiotic biosynthesis and resistance as well as differentiated states during colonial morphogenesis in Streptomyces, bacteria that produce the majority of known antibiotics. More recently, we have extended concepts of innate antibiotic resistance and developmental states discovered in Streptomyces to related Mycobacteria, drug resistant pathogens that cause tuberculosis and leprosy.
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